Megalis is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection). Tadalafil is one of the best known medicines for treatment of erectile dysfunction in men. Tadalafil 10mg is hard enough for penetration and of long enough duration for successful intercourse, and provided improved erections.
If we compare tadalafil with sildenafil citrate, both drugs work in a similar manner and help male patients overcome impotence.
Megalis 10mg is also called 36-hour Cialis. It works in as little as 30 minutes and can also work for up to 36 hours.
The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5, however, because sexual stimulation is required to initiate the local penile
release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended Tadalafil starting dose for most men is 10 mg, taken as needed before sexual activity (but not more
than once daily). The dose may be increased to 20 mg or decreased to 5mg, per its efficacy and the man's personal tolerance of the drug. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.